Hydrogen molecular has been verified to have a wide range of biological effects， and previous studies showed that hydrogen has a significant therapeutic effect on many diseases. In recent years， there are many reports about the clinical application of hydrogen molecules at home and abroad， which provided a new way to treat diseases. Drinking hydrogen-rich water or injecting hydrogen-rich saline are the commonly used methods for hydrogen intake. It has attracted extensive attention because of its simple operation and high safety. In this paper， the clinical research progress of hydrogen-rich water and hydrogen-rich saline in metabolic diseases， nervous system diseases， inflammatory diseases， tumors， skin diseases， and exercise fatigue were summerized， aiming to provide references for clinical application and mechanism research of hydrogen-rich water and hydrogen-rich saline.
Keywords： hydrogen-rich water ; hydrogen-rich saline ; clinical trial